Lanny L. Johnson, M.D. is the founder of AntiOxidant USA Research and Development

He is an internationally recognized orthopedic surgeon. He is an inventor and holder of more than 50 US patents in medicine and surgery. He was one of the pioneers in arthroscopic surgery and as such most recognized as the inventor of the motorized instrumentation still used world wide today in all such procedures.

In 2018 he was invited to submit the following manuscript to the Bone and Joint Journal that reflected upon his career; a short autobiographical article.

Johnson LL. What’s Important: Making a Difference May Include Being Different. J Bone Joint Surg. 2018 Mar 7; 100 (5): 443. DOI 10.2106/JBJS.18.00011.

After concluding his clinical practice he has continued his interest in medical research and development.  In 2005, upon learning of the effect of the dyes that give color to cherries to stimulate the rodent pancreatic cells to produce insulin, he reasoned there may be other applications.  Independent studies at Scripps Institute in La Jolla, California confirmed his hypothesis that these dyes would cause the human joint lining to turn on the growth factor gene for Insulin Like Growth Factor-1.  IGF-1 has long been known to heal articular cartilage.  This resulted in US patents for intra articular injection treatment of synovial joint arthritis; i.e. knee, hip, shoulder, etc.

8, 263,069  Compositions including anthocyanin or anthocyanidins for the prevention or treatment of articular cartilage-associated conditions.  September 11, 2012.

9,486,468: Compositions including anthocyanin or anthocyanidin for the prevention or treatment of articular cartilage-associated conditions. November 8, 2016

It was learned that the bioactive reagent was not those parent dyes found in fruits but the primary metabolite; protocatechuic acid (PCA). PCA is a phytochemical in the food supplement category. It is a nutraceutical.

Subsequent studies demonstrated that PCA increased the genetic expression of the growth hormone, Insulin Like Growth Factor-1 (IGF-1) in cells and tissues. He also showed in animal studies that PCA in certain small concentrations of PCA optimized the local skin growth hormones to heal a wound very rapidly. PCA caused in just 2 days the increase of collagen in the skin wound. Collagen is fundamental to bone structure. The following US patents were granted related to growth hormone effects on wound healing.

9,498,413

Antimicrobials and methods of use thereof for wound healing.

November 22, 2016.  This was the parent patent showing broad spectrum anti- biotic properties and wound healing acceleration.

9,925,152

Antimicrobials and methods of use thereof for wound healing. March 27, 2018.  This was a continuation of the parent application that adds 2,4,6 trihydroxybenzaldehyde to the broad spectrum antibiotic, plus collagen proliferation (i.e. wrinkle treatment) and reduction in scar formation.

10,143,670

Antimicrobials and methods of use thereof.  December 4, 21018  This patent secures the use of PCA to  coat a bandage or dressing at time or treatment and or a commercial preparation for as stated in claim #22 if a wound is a burn, skin break, bone break, muscle tear, puncture, surgical incision site, microdermabrasion site, skin graft site, a wound associated with diabetes, a bed sore, a pressure sore, skin defoliation, or a laceration, and wherein the protocatechuic acid becomes activated by contact with moisture from the wound.

Studies were then advance to examine the effects of PCA on osteoarthritis.  The results showed that PCA caused the human and mammal joint lining to produce the growth hormone IGF-1 and cause the modification of osteoarthritis progression in the experimental animal.  

He reasoned that if PCA resulted in growth hormone production locally would it be possible that PCA could stimulate human bone cells to produce bone.  The answer was yes and the foundation of a US patent pending.  LINK to Evidence

The scientists involved in study number one were surprised at the findings and advised that a study should be performed to learn if PCA would cause human MSC to convert to bone producing osteoblasts.  The answer was yes. LINK to Evidence

This basic science evidence that suggests that PCA would help support healthy bone and teeth.

These research findings provide the foundation to advance to animal studies examining the potential for enhance fracture healing and bone grafting procedures.